Fresh analysis indicates that patients who stop using popular slimming jabs like Wegovy and Mounjaro may regain reduced body mass much more quickly than those who stop conventional diet and exercise plans.
Findings released in a major health publication shows that while obese individuals can lose about a fifth of their body weight while using the jabs, the mass returns at an average rate of nearly a kilo each month after stopping.
"Individuals buying such treatments need to be aware of the danger of quick weight regain when the medication is stopped," stated expert Dr. Susan Jebb.
That rate of regain suggests a return to original weight within about 18 months.
Comparing Therapies
The study, which looked at dozens of trials involving over 9,000 of patients, compared the outcomes of these new drugs with older methods.
The team emphasize that individuals who lose weight through dieting typically experience a slower weight regain—perhaps 100 grams monthly—post-intervention.
The Reason for the Rapid Regain
Nutrition scientists suggest the way of the jabs explains the accelerated rebound.
GLP-1 drugs copy a body's own chemical called GLP-1, which moderates appetite.
"Long-term administration of GLP-1 levels far above than the body's typical production may cause the system to generate a reduced amount of its endogenous GLP-1, and may also reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this hormone supplement results in appetite is uncontrolled, making overeating far more likely."
An Ongoing Condition?
Medical guidelines suggest the jabs for individuals with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
A number of clinicians say that, considering the significant potential of weight regain, the therapy should be considered ongoing.
This view is reinforced by drug manufacturers, who say that the findings "underscore the chronic nature of obesity," similar to managing conditions like hypertension.
User Testimonies
Users who have stopped the jabs explain a intense resurgence of hunger.
"I experienced a trigger flipping and you're instantly starving," recalled a patient.
The struggle is exacerbated if individuals have not adopted sustainable lifestyle or habit changes during treatment.
Widespread Use
Figures show that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with demand being substantial.
- Adoption is higher among females compared to males.
- The middle-aged age group shows the greatest level of interest.
- Many access the medications through private healthcare rather than the NHS.
Ultimately, clinicians stress that while GLP-1 drugs are potent agents for weight loss, they are not a standalone solution and lasting health benefits hinges on ongoing lifestyle changes.
